تفاعل #45030

معادلة التفاعل

Methyl 4-(2-[dimethylamino]ethylamino)benzoate

(2-Methylpropan-2-yl)oxycarbonyl tert-butyl carbonate

→

methyl 4-[2-dimethylaminoethyl-[tert-butoxycarbonyl]amino]benzoate

المردود 74.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe solution was refluxed for 3 h
2. 2
   أخرىThe solvent was then evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in DCM
4. 4
   غسيلwashed with sat. aq. ammonium chloride solution
5. 5
   تجفيفdried over sodium sulphate
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated

الإجراء التجريبي

Methyl 4-(2-[dimethylamino]ethylamino)benzoate (1.00 g, 4.50 mmol) was dissolved in THF (30 ml). (2-Methylpropan-2-yl)oxycarbonyl tert-butyl carbonate (1.035 g, 4.72 mmol) was added and the solution was refluxed for 3 h. The solvent was then evaporated, the residue was dissolved in DCM, washed with sat. aq. ammonium chloride solution, dried over sodium sulphate, filtered and evaporated to give methyl 4-[2-dimethylaminoethyl-[tert-butoxycarbonyl]amino]benzoate (1.07 g, 74%) as a brown oil.

المصدر