تفاعل #45029

معادلة التفاعل

Potassium hydroxide

5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine

(2-Methylpropan-2-yl)oxycarbonyl tert-butyl carbonate

→

tert-butyl 5-amino-3-[(3,5-dimethoxyphenyl)methoxy]pyrazole-1-carboxylate

المردود 99.0%

المذيبات

water

DCM

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   أخرىThe reaction mixture was separated
3. 3
   غسيلthe organic layer was washed with water (2×15 ml), brine (2×15 ml)
4. 4
   تجفيفdried over sodium sulphate
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated
7. 7
   أخرىdried in vacuo

الإجراء التجريبي

Potassium hydroxide (11.19 g, 199.4 mmol) dissolved in water (44.8 ml) was added to a solution of 5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine (7.121 g) dissolved in dichloromethane (40 ml). (2-Methylpropan-2-yl)oxycarbonyl tert-butyl carbonate (6.8 g, 31.2 mmol) dissolved in DCM (35 ml) was added and the reaction mixture was stirred vigorously at room temperature for 4 h. The reaction mixture was separated and the organic layer was washed with water (2×15 ml), brine (2×15 ml), dried over sodium sulphate, filtered, evaporated and dried in vacuo to give tert-butyl 5-amino-3-[(3,5-dimethoxyphenyl)methoxy]pyrazole-1-carboxylate (8.70 g, 99%) as a cream solid.

المصدر