تفاعل #44954

معادلة التفاعل

Pseudomonic acid

potassium hydroxide

calcium chloride

→

Mupirocin Calcium

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe solution was filtered
2. 2
   أخرىto remove potassium chloride (0.51 g)
3. 3
   أخرىThe ethanol was subsequently evaporated at reduced pressure
4. 4
   أخرىto give a solid, white foam
5. 5
   أخرىThe product was dried for 12 hours at 45° C. under vacuum

الإجراء التجريبي

Pseudomonic acid (5.00 g, 10 mmole) was dissolved in ethanol (20 ml), ethanolic solution of potassium hydroxide (0.56 g, 10 mmole potassium hydroxide and 10 ml ethanol) and ethanolic solution of calcium chloride (0.56 g, 5.0 mmole calcium chloride and 10 ml ethanol) were added to the mixture. The mixture was stirred for 1 hour and the solution was filtered to remove potassium chloride (0.51 g). The ethanol was subsequently evaporated at reduced pressure to give a solid, white foam. The product was dried for 12 hours at 45° C. under vacuum. The product had a mass of 4.38 grams. Assay: 99.1%, water: 2.36% [total impurity: 2.44%, highest impurity: 1.10% different method than the assay].

المصدر