تفاعل #4495

معادلة التفاعل

benzamide

ethyl 4-chloroacetoacetate

sodium bicarbonate

→

ethyl 2-phenyl-4-oxazoleacetate

المردود 38.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   استخلاصthe mixture was extracted with ethyl acetate
3. 3
   غسيلThe extract was washed with water
4. 4
   تجفيفdried (MgSO4)
5. 5
   تركيزconcentrated
6. 6
   أخرىThe residue was purified by chromatography on silica gel with ethyl ether-hexane (1:9)

الإجراء التجريبي

A mixture of benzamide (60.0 g) and ethyl 4-chloroacetoacetate (49.4 g) was heated at 120° C. for 2 hours. After cooling, aqueous sodium bicarbonate solution was added thereto and the mixture was extracted with ethyl acetate. The extract was washed with water, dried (MgSO4) and concentrated. The residue was purified by chromatography on silica gel with ethyl ether-hexane (1:9) to yield ethyl 2-phenyl-4-oxazoleacetate as an oil (26.4 g, 28.0%). NMR (CDCl3)δ: 1.27 (3H, t, J=7 Hz), 3.68 (3H, s), 4.15 (2H, q, J=7 Hz), 7.4 (3H, m), 7.67 (1H, s), 8.0 (2H, m).

المصدر