تفاعل #44947

معادلة التفاعل

Pseudomonic acid

Calcium oxide

pseudomonic acid

→

Mupirocin calcium dihydrate

المردود 51.7%

المذيبات

isobutyl methyl ketone

water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe phases were separated
2. 2
   workup.DISTILLATIONThe volume of the aqueous phase was reduced to 40 ml by vacuum distillation
3. 3
   workup.WAITafter standing for 15 hours
4. 4
   ترشيحthe crystalline product was filtered
5. 5
   غسيلwashed with cooled water (10 ml)
6. 6
   أخرىThe product was then dried in an air
7. 7
   أخرىat RT

الإجراء التجريبي

Pseudomonic acid (10 g) was dissolved in isobutyl methyl ketone (120 ml). Calcium oxide (0.57 g) was suspended in water (68 ml), and added to the solution of pseudomonic acid. The mixture was stirred for one hour, and the phases were separated. The volume of the aqueous phase was reduced to 40 ml by vacuum distillation. The mixture was cooled to 5° C., and after standing for 15 hours, the crystalline product was filtered and washed with cooled water (10 ml). The product was then dried in an air circulated oven at RT. Mupirocin calcium dihydrate (3.7 g, 35%) was obtained.

المصدر