تفاعل #44944

ord-4e0ef7ba04fb4e29ba37bc91f2b6c1e1

معادلة التفاعل

C/C(=C\C(=O)OCCCCCCCCC(=O)O)C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O
Pseudomonic acid
[Ca+2].[O-2]
Calcium oxide
→
C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.O.O.[Ca+2]
Mupirocin calcium dihydrate
المردود 131.3%

المتفاعلات

C/C(=C\C(=O)OCCCCCCCCC(=O)O)C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O
Pseudomonic acid
[Ca+2].[O-2]
Calcium oxide

الكواشف

لا شيء

المذيبات

O
water

ظروف التفاعل

درجة الحرارة
5°CELSIUS
الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    ترشيحfiltered
  2. 2
    workup.WAITAfter standing for 15 h
  3. 3
    ترشيحthe crystalline product was filtered
  4. 4
    غسيلwashed with cooled water (10 ml)
  5. 5
    أخرىdried in an air
  6. 6
    أخرىat room temperature

الإجراء التجريبي

Pseudomonic acid (10 g) was suspended in water (26 ml). Calcium oxide (0.58 g) was added to the suspension. The mixture was stirred for one hour, and filtered. The mixture was cooled to 5° C. After standing for 15 h, the crystalline product was filtered and washed with cooled water (10 ml) and dried in an air circulated oven at room temperature. Mupirocin calcium dihydrate (9.4 g, 87%) was obtained.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07737177B2uspto-grants-2010_06