تفاعل #4494

معادلة التفاعل

butyramide

1.3-dichloroacetone

sodium bicarbonate

→

4-chloromethyl-2-propyloxazole

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   استخلاصextracted with ethyl ether
3. 3
   غسيلThe extract was washed with water
4. 4
   تجفيفdried (MgSO4)
5. 5
   تركيزconcentrated
6. 6
   أخرىThe residue was purified by chromatography on silica gel with acetone-hexane (1:9)

الإجراء التجريبي

A mixture of butyramide (19.88 g) and 1.3-dichloroacetone (24.14 g) was heated at 130° C. for 1.5 hours. After cooling, the mixture was diluted with water, neutralized with aqueous sodium bicarbonate solution and extracted with ethyl ether. The extract was washed with water, dried (MgSO4) and concentrated. The residue was purified by chromatography on silica gel with acetone-hexane (1:9) to yield 4-chloromethyl-2-propyloxazole as an oil (10.70 g 35.3%). NMR (CDCl3)δ: 0.97 (3H, t, J=7.5 Hz), 1.79 (2H, sext, J=7.5 Hz), 2.72 (2H, t, J=7.5 Hz), 4.47 (2H, s), 7.53 (1H, s).

المصدر