تفاعل #44854

معادلة التفاعل

tert-butyl 4-cyanotetrahydro-2H-pyran-4-carboxylate

→

title compound

المردود 83.0%

tert-butyl 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxylate

المردود 83.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىat room temperature
2. 2
   أخرىfor 12 h
3. 3
   ترشيحThen, the mixture was filtered through a pad of Celite
4. 4
   تركيزthe filtrate was concentrated in vacuo

الإجراء التجريبي

A mixture of tert-butyl 4-cyanotetrahydro-2H-pyran-4-carboxylate (18.95 g, 0.0897 mol, step 1) and Raney Ni (1.00 g) in methanol (200 mL) was hydrogenated (3 atm) at room temperature for 12 h. Then, the mixture was filtered through a pad of Celite, and the filtrate was concentrated in vacuo to give 16.01 g (83%) of the title compound as a yellow syrup.

المصدر