تفاعل #44844

معادلة التفاعل

4-hydroxyindole

diethyl bromomalonate

potassium carbonate

→

7

المردود 13.0%

diethyl 2-bromo-2-(indol-4-yloxy)malonate

المردود 13.0%

8

المردود 34.0%

diethyl 2-(indol-4-yloxy)malonate

المردود 34.0%

المذيبات

acetone

acetone

ظروف التفاعل

الإجراء التجريبي

A solution of 4-hydroxyindole (266 mg, 2 mmol) in acetone (20 mL) was cooled to 0° C. under nitrogen and anhydrous potassium carbonate (414 mg, 3 mmol) was added. A solution of freshly distilled pure diethyl bromomalonate (574 mg, 2.4 mmol) in acetone (20 mL) was added dropwise and the mixture was stirred at room temperature overnight. Work up and flash chromatography as above afforded 7 (101 mg, 13%) and 8 (199 mg, 34%).

المصدر