تفاعل #4476

معادلة التفاعل

water

potassium carbonate

product

1,2,3,9-Tetrahydro-6-methoxy-4H-carbazol-4-one

Dimethyl sulphate

→

title compound

المردود 78.2%

1,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one

المردود 78.2%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated
2. 2
   درجة الحرارةto reflux for 4 h
3. 3
   ترشيحthe resulting precipitate filtered off

الإجراء التجريبي

Anhydrous potassium carbonate (2.24 g) was added to a solution of the product of Stage (i) (3 g) in acetone (30 ml) at room temperature and stirred for 30 min. Dimethyl sulphate (1.6 ml) was added and the mixture was heated to reflux for 4 h. The resulting solution was poured into water (150 ml) and the resulting precipitate filtered off to give the title compound as a solid (2.5 g), m.p. 150°-151°.

المصدر