تفاعل #44759

معادلة التفاعل

2,2,3,3,3-pentafluoropropyl 4-methylbenzenesulfonate

4-hydroxybenzaldehyde

potassium carbonate

→

4-(2,2,3,3,3-pentafluoropropoxy)benzaldehyde

المردود 30.2%

المذيبات

ethyl acetate

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   workup.STIRRINGThe mixture was stirred
3. 3
   درجة الحرارةheated at 100° C. for 7 h
4. 4
   درجة الحرارةto cool
5. 5
   غسيلwashed with water (3×) and brine
6. 6
   تركيزconcentrated
7. 7
   أخرىPurification by flash chromatography on silica gel using a gradient of ethyl acetate in hexane

الإجراء التجريبي

A solution of 4-hydroxybenzaldehyde (2 g, 16.7 mmol) in DMF (33 mL) was stirred as solid potassium carbonate (4.1 g, 29.7 mmol) was added, and the reaction mixture was then stirred at RT. After 30 min, solid 2,2,3,3,3-pentafluoropropyl 4-methylbenzenesulfonate (5 g, 16.4 mmol) was added into the reaction mixture. The mixture was stirred and heated at 100° C. for 7 h. The reaction mixture was allowed to cool, diluted with ethyl acetate, washed with water (3×) and brine, and concentrated. Purification by flash chromatography on silica gel using a gradient of ethyl acetate in hexane afforded 4-(2,2,3,3,3-pentafluoropropoxy)benzaldehyde (1.26 g).

المصدر