تفاعل #44733

معادلة التفاعل

6-chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenyl]pyrimidine-2,4-diamine

6-Chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]pyrimidine-2,4-diamine

N-ethyldiisopropylamine

piperazine

→

N4-[3-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-piperazin-1-ylpyrimidine-2,4-diamine

المذيبات

1-butanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture is heated
2. 2
   درجة الحرارةat reflux for 5 hours
3. 3
   أخرىThe solvent is then removed under reduced pressure
4. 4
   أخرىthe residue is purified by preparative HPLC

الإجراء التجريبي

75 mg (0.20 mmol) of 6-chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenyl]pyrimidine-2,4-diamine (from example 60) are dissolved in 3 ml of 1-butanol. 0.35 ml of N-ethyldiisopropylamine and 70 mg (0.81 mmol) of piperazine are added, and the mixture is heated at reflux for 5 hours. The solvent is then removed under reduced pressure and the residue is purified by preparative HPLC.

المصدر