تفاعل #44732

ord-f4272c53ab6d4617af711badfb970f40

معادلة التفاعل

Nc1cc(F)c(Oc2ccnc3[nH]ccc23)c(F)c1
[3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amine
Nc1nc(Cl)cc(Cl)n1
4,6-dichloro-2-pyrimidineamine
Nc1nc(Cl)cc(Nc2cc(F)c(Oc3ccnc4[nH]ccc34)c(F)c2)n1
title compound
Nc1nc(Cl)cc(Nc2cc(F)c(Oc3ccnc4[nH]ccc34)c(F)c2)n1
6-Chloro-N4-[3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]pyrimidine-2,4-diamine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Analogously to example 8, the title compound is synthesized from 384 mg (1.47 mmol) of [3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amine (from example XXXIV) and 241 mg (1.47 mmol) of 4,6-dichloro-2-pyrimidineamine.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07737153B2uspto-grants-2010_06