تفاعل #44715

معادلة التفاعل

sodium bicarbonate

5-(4-amino-2-fluorophenoxy)-1H-indazole

5-(4-Amino-2-fluorophenoxy)-1H-indazole

4,6-dichloro-2-pyrimidineamine

hydrogen chloride

→

N-[2-Amino-6-chloro-4-pyrimidinyl]-N-[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]amine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted 3× with ethyl acetate
2. 2
   تجفيفThe organic phase is dried with sodium sulfate
3. 3
   تركيزconcentrated
4. 4
   أخرىa rotary evaporator

الإجراء التجريبي

1.65 g (6.78 mmol) of 5-(4-amino-2-fluorophenoxy)-1H-indazole (from example XII) are suspended in 90 ml of water. 1.11 g (6.78 mmol) of 4,6-dichloro-2-pyrimidineamine and 0.68 ml of concentrated aqueous hydrogen chloride solution are added, and the mixture is stirred at 100° C. overnight. For work-up, the reaction solution is made alkaline with saturated sodium bicarbonate solution and extracted 3× with ethyl acetate. The organic phase is dried with sodium sulfate and concentrated using a rotary evaporator.

المصدر