تفاعل #4471

معادلة التفاعل

product

6-Fluoro-1,2,3,9-tetrahydro-4H-carbazol-4-one

potassium carbonate

dimethylsulphate

→

title compound

المردود 97.5%

6-Fluoro-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one

المردود 97.5%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   تركيزThe mixture was concentrated to one half of its volume
2. 2
   ترشيحThe mixture was filtered off
3. 3
   غسيلwashed with water (50 ml)
4. 4
   أخرىair-dried for 1 h
5. 5
   تجفيفdried in vacuo over phosphorus pentoxide

الإجراء التجريبي

The product of Stage (ii) (7.28 g), potassium carbonate (9.90 g), acetone (70 ml), and dimethylsulphate (5.1 ml) were vigorously stirred at room temperature overnight under nitrogen. The mixture was concentrated to one half of its volume and then stirred with water (350 ml) for 30 min. The mixture was filtered off, washed with water (50 ml), air-dried for 1 h, and dried in vacuo over phosphorus pentoxide to give the title compound as needles (7.59 g), m.p. 157.5°-158.5°.

المصدر