تفاعل #44691

معادلة التفاعل

4-(2-fluoro-4-nitrophenoxy)-1H-indazole

4-(2-Fluoro-4-nitrophenoxy)-1H-indazole

→

3-Fluoro-4-(1H-indazol-4-yloxy)aniline

المذيبات

ethanol tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe suspension is filtered off through CELITE (diatomaceous earth)
2. 2
   غسيلthe filtercake is washed with ethanol
3. 3
   تركيزthe filtrate is concentrated under reduced pressure

الإجراء التجريبي

Under argon, 60 mg (0.22 mmol) of 4-(2-fluoro-4-nitrophenoxy)-1H-indazole (from example XXV) are initially charged in 5 ml of ethanol/tetrahydrofuran (1:1), 9.97 mg (0.04 mmol) of platinum(IV) oxide are added and the mixture is hydrogenated under atmospheric pressure for 2 hours. The suspension is filtered off through CELITE (diatomaceous earth), the filtercake is washed with ethanol and the filtrate is concentrated under reduced pressure.

المصدر