تفاعل #44688

معادلة التفاعل

4-(2-fluoro-4-nitrophenoxy)-1-benzofuran

4-(2-Fluoro-4-nitrophenoxy)-1-benzofuran

→

4-(1-Benzofuran-4-yloxy)-3-fluorophenylamine

المذيبات

ethanol tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe suspension is filtered off through CELITE (diatomaceous earth)
2. 2
   غسيلthe filtercake is washed with ethanol
3. 3
   تركيزthe filtrate is concentrated
4. 4
   أخرىa rotary evaporator

الإجراء التجريبي

Under argon, 150 mg (0.55 mmol) of 4-(2-fluoro-4-nitrophenoxy)-1-benzofuran (from example XXII) are initially charged in 5 ml of ethanol/tetrahydrofuran (1:1), platinum(IV) oxide is added and the mixture is hydrogenated under atmospheric pressure for 2 hours. The suspension is filtered off through CELITE (diatomaceous earth), the filtercake is washed with ethanol and the filtrate is concentrated using a rotary evaporator.

المصدر