تفاعل #44661

معادلة التفاعل

(R)-1-hydroxylethyl-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester

hydrochloric acid ethyl acetate

→

titled compound

المردود 98.7%

(R)-1-[(S)-5-(3,4,5-trifluorophenyl)-pyrrolidine-2-yl]ethanol

المردود 98.7%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىSolvent was removed by distillation under reduced pressure
2. 2
   workup.ADDITIONthe resultant product was diluted with 5 N aqueous sodium hydroxide and dichloromethane
3. 3
   أخرىThe organic layer was partitioned
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   أخرىSolvent was removed by distillation under reduced pressure

الإجراء التجريبي

To a solution of (S)-2-((R)-1-hydroxylethyl-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester (3.71 g) in ethyl acetate (20 mL) was added 4 N hydrochloric acid/ethyl acetate (26.8 mL), and the resultant solution was stirred at room temperature for 2 hours. Solvent was removed by distillation under reduced pressure, and the resultant product was diluted with 5 N aqueous sodium hydroxide and dichloromethane. The organic layer was partitioned and then dried over anhydrous magnesium sulfate. Solvent was removed by distillation under reduced pressure, to thereby obtain the titled compound (2.6 g). The physical properties of this crude product were as follows.

المصدر