تفاعل #4464

معادلة التفاعل

(S)-alanyl-(S)-proline-t-butylester

E-ethyl-3-benzoyl-acrylate

maleinic acid

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product

المردود 60.0%

N-[1(S)-ethoxycarbonyl-3-phenyl-3-oxo-propyl]-(S)-alanyl-(S)-proline-t-butyl-ester maleate

المردود 60.0%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGAfter one hour stirring at room temperature the solvent
2. 2
   أخرىis evaporated off under reduced pressure
3. 3
   workup.DISSOLUTIONthe residue is dissolved in 20 ml of ethyl acetate
4. 4
   ترشيحThe precipitated crystals are filtered off after one hour standing
5. 5
   غسيلwashed with 20 ml of ethyl acetate

الإجراء التجريبي

4.84 g (20 mmoles) of (S)-alanyl-(S)-proline-t-butylester are dissolved in 40 ml of dry benzene and 4.08 g (20 mmoles) of E-ethyl-3-benzoyl-acrylate are added at room temperature under stirring. After one hour stirring at room temperature the solvent is evaporated off under reduced pressure, the residue is dissolved in 20 ml of ethyl acetate and 2.32 g (20 mmoles) of maleinic acid are added. The precipitated crystals are filtered off after one hour standing and washed with 20 ml of ethyl acetate. 6.7 g (60%) of product are obtained with a melting point of 109°-110° C.

المصدر