تفاعل #44616

معادلة التفاعل

hydrogen

(3S,8aR)-3-(3,4,5-trifluorophenyl)-2,3,6,8a-tetrahydro-1H-indolizin-5-one

→

title compound

المردود 99.8%

(3S,8aR)-3-(3,4,5-trifluorophenyl)hexahydroindolizin-5-one

المردود 99.8%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe resulting reaction solution
2. 2
   ترشيحThe reaction solution was filtered through Celite
3. 3
   تركيزThe filtrate was concentrated under reduced pressure

الإجراء التجريبي

Platinum oxide (100 mg) was added to a methanol solution (20 mL) of (3S,8aR)-3-(3,4,5-trifluorophenyl)-2,3,6,8a-tetrahydro-1H-indolizin-5-one (680 mg). The resulting reaction solution was stirred under 1 atm of hydrogen atmosphere at room temperature for 2.5 hr. The reaction solution was filtered through Celite. The filtrate was concentrated under reduced pressure to give 684 mg of the title compound. The physical property values of this compound were as follows:

المصدر