تفاعل #44586

معادلة التفاعل

2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine

4-hydroxypyridine

→

title compound

المردود 50.0%

6-(Pyridin-4-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine

المردود 50.0%

ظروف التفاعل

الإجراء التجريبي

Using Method X with 150 mg of 2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine and 4-hydroxypyridine, the title compound was obtained (89 mg). Yield: 50%. 1H NMR (250 MHz, DMSO-d6) δ 3.64 (s, 3H), 3.79 (s, 6H), 6.29 (d, 2H, J=7.9 Hz), 7.07 (s, 2H), 8.19 (s, 1H), 8.32 (s, 1H), 8.43 (d, 2H, J=8.0 Hz), 9.91 (bs, 1H). 13C NMR (62.9 MHz, DMSO-d6) δ 55.61, 60.11, 96.50, 117.94, 121.98, 132.71, 132.79, 135.77, 136.52, 145.43, 150.31, 152.85, 178.22. m/z 355.1 [(M+H)+ calcd for C18H18N4O4 354.1].

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