تفاعل #44525

معادلة التفاعل

4-chloro-2-methylsulfanylpyrimidine

ammonia

→

2-(methylsulfanyl)-4-pyrimidinamine

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled
2. 2
   تركيزconcentrated
3. 3
   workup.ADDITIONtreated with water
4. 4
   استخلاصextracted with ethyl acetate
5. 5
   غسيلThe extract was washed with brine
6. 6
   تجفيفdried over anhydrous sodium sulfate
7. 7
   تركيزconcentrated
8. 8
   أخرىThe concentrate was triturated with ethyl ether
9. 9
   ترشيحfiltered

الإجراء التجريبي

A mixture of 4-chloro-2-methylsulfanylpyrimidine (8 g) and 7N ammonia in methanol (100 mL) at 100° C. was stirred for 2 days in a sealed tube, cooled, concentrated, treated with water, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The concentrate was triturated with ethyl ether and filtered. 1H NMR (300 MHz, CDCl3) δ 8.06 (d, 1H), 6.12 (d, 1H), 4.83 (s, 2H), 2.51 (s, 3H).

المصدر