تفاعل #44521

معادلة التفاعل

1-Benzyl-3-pyrrolidinol

triethylamine

methanesulfonyl chloride

→

1-benzyl-3-pyrrolidinyl methanesulfonate

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with saturated aqueous sodium bicarbonate, water, and brine
2. 2
   تجفيفdried over anhydrous sodium sulfate
3. 3
   تركيزconcentrated

الإجراء التجريبي

1-Benzyl-3-pyrrolidinol (1.1 g) in toluene (10 mL) at 0° C. was treated with triethylamine (1 mL) and methanesulfonyl chloride (0.53 mL), warmed to room temperature, washed with saturated aqueous sodium bicarbonate, water, and brine, dried over anhydrous sodium sulfate, and concentrated. 1H NMR (300 MHz, DMSO-d6) δ 7.31 (s, 5H), 5.21 (m, 1H), 3.65 (q, 2H), 2.82 (m, 2H), 2.5 (m, 2H), 2.36 (m, 2H), 2.1 (m, 1H).

المصدر