تفاعل #4452

معادلة التفاعل

2-benzyl-4-(2-chloro-4-pyridyl)thiazole

→

2-benzyl-4-[2-(1-piperidyl)-4-pyridyl]thiazole dihydrochloride

المردود 73.5%

المذيبات

piperidine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for 16 hours
2. 2
   تركيزThe reaction mixture was concentrated
3. 3
   ترشيحfiltered through celite
4. 4
   غسيلthe filtrate washed with water (2×)
5. 5
   تجفيفThe ether layer was dried
6. 6
   تركيزconcentrated
7. 7
   workup.ADDITIONtreated with an excess of dry hydrochloric acid

الإجراء التجريبي

A solution of 2-benzyl-4-(2-chloro-4-pyridyl)thiazole (1.00 g, 0.0035 mol) in piperidine (15 mL) was heated to reflux for 16 hours. The reaction mixture was concentrated, taken up in ether (50 mL), filtered through celite, and the filtrate washed with water (2×). The ether layer was dried and concentrated. The residue was taken up in ethanol (20 mL) and treated with an excess of dry hydrochloric acid. Careful dilution with ether afforded 2-benzyl-4-[2-(1-piperidyl)-4-pyridyl]thiazole dihydrochloride (525 mg, 49%). mp. 145° C.

المصدر