تفاعل #44518

معادلة التفاعل

6-(2-chloropyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

3-methoxyaniline

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title product

المردود 80.0%

6-(2-(3-methoxyphenylamino)pyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

المردود 80.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   استخلاصsubjected to extraction with ethyl acetate
2. 2
   workup.ADDITIONThen water was added
3. 3
   استخلاصthe mixture was subjected to extraction with ethyl acetate
4. 4
   غسيلThe organic layer was washed with water and brine sequentially
5. 5
   تجفيفdried over anhydrous Na2SO4
6. 6
   تركيزconcentrated
7. 7
   أخرىThe resulting residue was purified by column chromatography

الإجراء التجريبي

6-(2-chloropyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide (0.1 mmol) and 3-methoxyaniline (0.1 mmol) were dissolved in 0.5 ml DMF. To this was added p-TsOH monohydrate (0.2 mmol). The reaction mixture was stirred at 60° C. for 5 hours, and subjected to extraction with ethyl acetate. Then water was added and the mixture was subjected to extraction with ethyl acetate. The organic layer was washed with water and brine sequentially, dried over anhydrous Na2SO4, and concentrated. The resulting residue was purified by column chromatography to provide the title product in a yield of 80%.

المصدر