تفاعل #44516

معادلة التفاعل

6-((2-chloropyrimidin-4-yl)(methyl)amino)-N,2-dimethylbenzofuran-3-carboxamide

3-dimethylaminoaniline

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title product

المردود 78.0%

6-((2-(3-(dimethylamino)phenylamino)pyrimidin-4-yl)(methyl)amino)-N,2-dimethylbenzofuran-3-carboxamide

المردود 78.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   استخلاصsubjected to extraction with EtOAc
2. 2
   workup.ADDITIONThen water was added
3. 3
   استخلاصthe mixture was subjected to extraction with ethyl acetate
4. 4
   غسيلThe organic layer was washed with water and brine sequentially
5. 5
   تجفيفdried over anhydrous Na2SO4
6. 6
   تركيزconcentrated
7. 7
   أخرىThe resulting residue was purified by column chromatography

الإجراء التجريبي

6-((2-chloropyrimidin-4-yl)(methyl)amino)-N,2-dimethylbenzofuran-3-carboxamide (0.1 mmol) and 3-dimethylaminoaniline (0.1 mmol) were dissolved in 0.5 ml DMF. To this was added p-TsOH monohydrate (0.2 mmol). The reaction mixture was stirred at 60° C. for 5 hours, and subjected to extraction with EtOAc. Then water was added and the mixture was subjected to extraction with ethyl acetate. The organic layer was washed with water and brine sequentially, dried over anhydrous Na2SO4, and concentrated. The resulting residue was purified by column chromatography to provide the title product in a yield of 78%.

المصدر