تفاعل #44508

معادلة التفاعل

product

5-Oxo-cyclooctanecarbonitrile

ammonium acetate

sodium cyanoborohydride

→

5-Amino-cyclooctanecarbonitrile

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   أخرىthe residue was partitioned with dichloromethane and water
3. 3
   غسيلThe organic phase was washed with NaHCO3 solution and brine
4. 4
   تجفيفdried (Na2SO4)
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated
7. 7
   أخرىThe crude title compound was used in the following step without further purification

الإجراء التجريبي

The product of Example 10B (0.259 g, 1.71 mmol), ammonium acetate (1.32 g, 17.14 mmol), and sodium cyanoborohydride (0.43 g, 6.84 mmol) was stirred in methanol (8 mL) for twelve hours. The solvent was evaporated and the residue was partitioned with dichloromethane and water. The organic phase was washed with NaHCO3 solution and brine, dried (Na2SO4), filtered, and evaporated. The crude title compound was used in the following step without further purification.

المصدر