تفاعل #44505

معادلة التفاعل

solution

tert-butyl-(cyclohept-4-enyloxy)-diphenyl-silane

ethyl diazoacetate

→

title compound

4-(tert-butyl-diphenyl-silanyloxy)-bicyclo[5.1.0]octane-8-carboxylic acid ethyl ester

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated in vacuo and product
2. 2
   أخرىpurified by flash column chromatography (hexanes:ethyl acetate 100:0 to 80:20)

الإجراء التجريبي

To a solution of Example 8C (2.2 g, 6.28 mmoles) and Rh2(OAc)4 (2 mg, 4.3 μmol) in dichloromethane (2 mL), ethyl diazoacetate (0.717 g, 6.28 mmoles) in dichloromethane (4 mL) was added over two hours via a syringe pump. The solvent was evaporated in vacuo and product purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 80:20) to provide the title compound.

المصدر