تفاعل #44504

معادلة التفاعل

product

Cyclohept-4-enol

imidazole

Tert-butyl-chlorodiphenylsilane

→

title compound

tert-butyl-(cyclohept-4-enyloxy)-diphenyl-silane

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was partitioned between ethyl acetate and water
2. 2
   غسيلThe organic layer was washed with brine (25 mL)
3. 3
   تجفيفdried with MgSO4
4. 4
   ترشيحfiltered
5. 5
   أخرىsolvent evaporated in vacuo
6. 6
   أخرىThe crude product was purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 90:10)

الإجراء التجريبي

A solution of the product of Example 8B (1.57 g, 14.05 mmoles), imidazole (1.43 g, 21.08 mmoles), and Tert-butyl-chlorodiphenylsilane (4.76 gm, 17.4 mmoles) in N,N-dimethylformamide (10 mL) was stirred for five hours at 23° C. The reaction was partitioned between ethyl acetate and water. The organic layer was washed with brine (25 mL), dried with MgSO4, filtered, and solvent evaporated in vacuo. The crude product was purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 90:10) to provide the title compound as an oil.

المصدر