تفاعل #444979

معادلة التفاعل

2-chloro-3-thiophenecarboxylic acid

→

5-bromo-2-chloro-3-thiophenecarboxylic acid

المردود 77.5%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىPrecipitated crystals
2. 2
   ترشيحwere collected by filtration
3. 3
   workup.DISSOLUTIONdissolved in ethyl acetate
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   تركيزThe solution was concentrated under reduced pressure

الإجراء التجريبي

A mixture of 2-chloro-3-thiophenecarboxylic acid (2.44 g), pyridinium bromide perbromide (5.33 g) and acetic acid (15 ml) was stirred at 40° C. for 4 hours and poured into ice-water. Precipitated crystals were collected by filtration, dissolved in ethyl acetate and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to give 5-bromo-2-chloro-3-thiophenecarboxylic acid (2.81 g) as crystals.

المصدر