تفاعل #44476

معادلة التفاعل

N-(4-(6-chloropyrazin-2-ylthio)phenyl)cyclopropanecarboxamide

3-amino-5-methylpyrazole

4,5-bis(diphenylphosphino)-9,9-dimethylxanthene

sodium carbonate

→

title compound

المردود 6.0%

N-(4-(6-(3-methyl-1H-pyrazol-5-ylamino)pyrazin-2-ylthio)phenyl)cyclopropanecarboxamide

المردود 6.0%

المذيبات

ethyl acetate

Water

1,4-dioxan

ظروف التفاعل

المعالجة

1. 1
   أخرىthe layers separated
2. 2
   استخلاصThe aqueous layer was extracted further with ethyl acetate (2×10 mL)
3. 3
   تجفيفthe combined organic layers dried (MgSO4)
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىThe residue was purified by column chromatography (EtOAc/Petroleum ether, 0-100% gradient EtOAc)
6. 6
   أخرىpurified further
7. 7
   أخرىHPLC purification (sunfire C18 column, trifluoroacetic acid/MeCN/MeOH as eluent)

الإجراء التجريبي

To a solution of N-(4-(6-chloropyrazin-2-ylthio)phenyl)cyclopropanecarboxamide (0.49 mmol) and 3-amino-5-methylpyrazole (0.52 mmol) in 1,4-dioxan (3 mL), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (0.03 mmol), tris(dibenzylideneacetone) dipalladium (0.02 mmol) and sodium carbonate (0.69 mmol) were added. The resulting solution was heated at 120° C. in the microwave (175 W, 25 psi) for 30 min. Water (10 mL) and ethyl acetate (10 mL) were added and the layers separated. The aqueous layer was extracted further with ethyl acetate (2×10 mL), the combined organic layers dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography (EtOAc/Petroleum ether, 0-100% gradient EtOAc) and then purified further using mass directed HPLC purification (sunfire C18 column, trifluoroacetic acid/MeCN/MeOH as eluent) to give the title compound (10.6 mg, 6%) as a light yellow solid; 1H NMR (400 MHz, DMSO-d6) δ 0.81 (4H, m), 1.83 (1H, m), 2.05 (3H, s), 5.55 (1H, s), 7.54 (2H, m), 7.59 (1H, s), 7.74 (2H, m), 8.02 (1H, s), 9.77 (1H, s), 10.47 (1H, s); MS (ES+): m/e=367.41 (100%).

المصدر