تفاعل #444666

معادلة التفاعل

2-chloro-4,6-dimethoxypyrimidine

3-hydroxy-2-oxobutane

sodium methanesulfinate

potassium carbonate

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title product

(+/-)-3-(4,6-dimethoxy-2-pyrimidinyloxy)-2-butanone

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvent was removed in a rotary evaporator at 70° C./20 mbar
2. 2
   أخرىThe residue was purified by chromatography on a silica gel column (eluent hexane/ethyl acetate 4:1)

الإجراء التجريبي

4.38 g (25 mmol) of 2-chloro-4,6-dimethoxypyrimidine, 2.31 g (26.2 mmol) of 3-hydroxy-2-oxobutane and 0.66 g (6.3 mmol) of sodium methanesulfinate were heated in the presence of 5.17 g (37.5 mmol) of potassium carbonate in 25 ml of N,N-dimethylformamide to 120° C. with stirring. After 3 hours, the solvent was removed in a rotary evaporator at 70° C./20 mbar. The residue was purified by chromatography on a silica gel column (eluent hexane/ethyl acetate 4:1). The title product was obtained from the product fraction in the form of a pale yellowish oil in a yield of 4.58 g (80.4 percent of theory) (GC content 99 percent). Other data concerning the title compound was:

المصدر