تفاعل #44421

معادلة التفاعل

Phosphoryl chloride

barbituric acid

→

Chlorouracil

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   أخرىdoes not exceed 5° C
2. 2
   درجة الحرارةunder reflux for 5 h
3. 3
   درجة الحرارةafter it has cooled down
4. 4
   workup.ADDITIONpoured onto ice
5. 5
   استخلاصThe product is extracted with ethyl acetate (3×100 ml)
6. 6
   أخرىdried (Na2 SO4)
7. 7
   ترشيحThe mixture is filtered
8. 8
   workup.DISTILLATIONthe solvent is distilled off in vacuo

الإجراء التجريبي

Phosphoryl chloride (55 ml) is carefully added to barbituric acid (10 g, 78.1 mmol) at 0° C. Water (1.7 ml) is then added dropwise such that the temperature does not exceed 5° C. The mixture is boiled under reflux for 5 h and, after it has cooled down, poured onto ice. The product is extracted with ethyl acetate (3×100 ml) and dried (Na2 SO4). The mixture is filtered and the solvent is distilled off in vacuo.

المصدر