تفاعل #44378

معادلة التفاعل

product

(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

product

4-bromo-2-fluoro-N,N-bis(1-methylethyl)-benzamide

sodium carbonate

→

title compound

(2S)-2-[[4′-[[bis(1-methylethyl)amino]carbonyl]-5-chloro-3′-fluoro[1,1′-biphenyl]-2-yl]oxy]-propanoic acid

المذيبات

dioxan

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated
2. 2
   درجة الحرارةat reflux for 24 h
3. 3
   ترشيحfiltered (hyflo)
4. 4
   تركيزThe filtrate was concentrated in vacuo
5. 5
   أخرىpurified by reverse phase HPLC

الإجراء التجريبي

The product of step c) (200 mg), the product of step d) (200 mg), Pd(dppf)Cl2 (60 mg), sodium carbonate (350 mg) and dioxan (5 ml) were charged to a flask and heated at reflux for 24 h, then cooled to room temp and filtered (hyflo). The filtrate was concentrated in vacuo, then purified by reverse phase HPLC to give the title compound. Yield 22 mg

المصدر