تفاعل #4436

معادلة التفاعل

6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine

triethylamine

2,4-dichloro-5-sulfamoylbenzoyl chloride

→

4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine

المردود 71.5%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   غسيلThe reaction mixture was washed with water
2. 2
   تجفيفdried over magnesium sulfate
3. 3
   أخرىevaporated
4. 4
   أخرىThe obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v)

الإجراء التجريبي

To a solution of 6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine (0.8 g) in chloroform (10 ml) were added triethylamine (0.39 ml) and 2,4-dichloro-5-sulfamoylbenzoyl chloride (0.74 g), and the mixture was stirred at ambient temperature for 20 hours. The reaction mixture was washed with water, dried over magnesium sulfate, and evaporated. The obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v), to give 4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (1.03 g).

المصدر