تفاعل #44359

معادلة التفاعل

HCl

5-chloro-2-iodophenol

methyl bromoacetate

potassium carbonate

→

sub-title compound

Methyl (4-chloro-2-iodophenoxy)acetate

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 2 h
3. 3
   استخلاصthe mixture was extracted with ether (three times)
4. 4
   تجفيفThe organic extracts were dried (MgSO4)
5. 5
   أخرىevaporated
6. 6
   أخرىpurified by chromatography (silica, petrol ether as eluent)

الإجراء التجريبي

A mixture of 5-chloro-2-iodophenol (4.95 g), methyl bromoacetate (1.85 ml) and potassium carbonate (2.79 g) in acetonitrile (20 ml) was heated under reflux for 2 h. Aq HCl was added and the mixture was extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol ether as eluent) to give the sub-title compound (5.75 g).

المصدر