تفاعل #44153

معادلة التفاعل

3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

triethylamine

methanesulfonyl chloride

→

title compound

N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-N-(methylsulfonyl)methanesulfonamide

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىpartitioned between saturated aqueous sodium hydrogencarbonate solution and DCM
2. 2
   غسيلThe organic layer was washed with water
3. 3
   أخرىdried
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىThe residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)]

الإجراء التجريبي

To a stirred solution of 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (370 mg) and triethylamine (178 μL) in DCM (3 mL) was added methanesulfonyl chloride (33 L). The mixture was stirred for 18 h, then partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM. The organic layer was washed with water, dried and concentrated in vacuo. The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)] to give the title compound (342 mg).

المصدر