تفاعل #441487

معادلة التفاعل

methyl 4-hydroxy-3-nitrobenzoate

→

methyl 3-amino-4-hydroxybenzoate

المردود 69.4%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىInsoluble catalyst was removed
2. 2
   أخرىthe filtrate was evaporated in vacuo
3. 3
   أخرىThe residue was chromatographed on silica-gel with EtOH—CHCl3 (1:20, v/v) as eluent

الإجراء التجريبي

A stirred mixture of methyl 4-hydroxy-3-nitrobenzoate (3.22 g, 0.0163 mol) and 5% Pd-C (12.9 g) in MeOH (30 mL) was hydrogenated under an atmospheric pressure for 70 hr at room temp. Insoluble catalyst was removed, and the filtrate was evaporated in vacuo. The residue was chromatographed on silica-gel with EtOH—CHCl3 (1:20, v/v) as eluent to afford 1.89 g (69%) methyl 3-amino-4-hydroxybenzoate as a pale brown syrup.

المصدر