تفاعل #44139

معادلة التفاعل

sodium hydride

1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone

methyl iodide

→

final compound

المردود 45.0%

1-Methyl-3-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone

المردود 45.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   غسيلeluted with methanol
2. 2
   تركيزThe basic fractions were concentrated under vacuum
3. 3
   أخرىpurified by column chromatography (SPE cartridge, Silica)

الإجراء التجريبي

To a stirred solution of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (E85) in THF was added methyl iodide (1 eq.), followed by sodium hydride (1.2 eq), and the reaction was stirred for 60 minutes. The mixture was loaded onto an ion-exchange cartridge (SCX-2) and eluted with methanol followed by ammonia in methanol (1M). The basic fractions were concentrated under vacuum and purified by column chromatography (SPE cartridge, Silica) using as eluent a gradient from DCM-methanol (99:1) to DCM-methanol (98:2) affording the final compound (45% yield).

المصدر