تفاعل #44136

معادلة التفاعل

1,1,1-Tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3(1H)-one

3-[3-(2-hydroxyethyl)phenyl]-1,3-oxazolidin-2-one

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title compound

المردود 89.0%

[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]acetaldehyde

المردود 89.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with aqueous sodium hydroxide solution (1M, 10 mL)
2. 2
   تجفيفThe separated organic layer the latter was dried over magnesium sulfate
3. 3
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

1,1,1-Tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3(1H)-one (Dess-Martin periodinane, 709 mg, 1.67 mmol) was added to a solution of 3-[3-(2-hydroxyethyl)phenyl]-1,3-oxazolidin-2-one (315 mg, 1.52 mmol) in dichloromethane (10 mL). The mixture was stirred at room temperature for 30 min, then washed with aqueous sodium hydroxide solution (1M, 10 mL). The separated organic layer the latter was dried over magnesium sulfate and concentrated under reduced pressure affording the title compound in 89% yield (278 mg). The compound was used without further purification in the next step.

المصدر