تفاعل #441231

معادلة التفاعل

sodium

diethylhydroxymethylphosphonate

2-fluoro-5-bromonitrobenzene

→

2-diethylphosphonomethyloxy-5-bromonitrobenzene

المذيبات

DMF

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporation, extraction and chromatography

الإجراء التجريبي

A solution of 2-fluoro-5-bromonitrobenzene (1 mmole) in DMF (5 mL) was cooled to 0° C., and treated with a solution of freshly prepared sodium salt of diethylhydroxymethylphosphonate (1.2 mmole) in DMF (5 mL). The mixture was stirred at room temperature for 16 h. Evaporation, extraction and chromatography provided 2-diethylphosphonomethyloxy-5-bromonitrobenzene.

المصدر