تفاعل #441208

معادلة التفاعل

2-bromomethyl-4,6-dimethylpyridine

diethyl hydroxymethylphosphonate

sodium hydride

→

2-diethylphosphonomethyl-4,6-dimethylpyridine

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   استخلاصAfter 3 h the reaction mixture was subjected to extraction and chromatography

الإجراء التجريبي

A solution of diethyl hydroxymethylphosphonate (1 mmole)in toluene was treated with sodium hydride (1.1 mmole) at 0° C., and after 15 min 2-bromomethyl-4,6-dimethylpyridine (1 mmole) was added. After 3 h the reaction mixture was subjected to extraction and chromatography to give 2-diethylphosphonomethyl-4,6-dimethylpyridine.

المصدر