تفاعل #441204

معادلة التفاعل

2-methyl-4-chloromethylthiazole

diethyl hydroxymethylphosphonate

sodium hydride

→

2-methyl-4-(diethylphosphonomethoxymethyl)thiazole

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   استخلاصExtraction and chromatography

الإجراء التجريبي

A solution of diethyl hydroxymethylphosphonate (1 mmole) in DMF was treated with sodium hydride (1.2 mmole) followed by 2-methyl-4-chloromethylthiazole (1 mmole) at 0° C. and stirred at 25° C. for 12 h. Extraction and chromatography gave 2-methyl-4-(diethylphosphonomethoxymethyl)thiazole.

المصدر