تفاعل #44107

معادلة التفاعل

hydrogen chloride

1,1-dimethylethyl-4-(6-fluoro-2-methyl-5-quinolinyl)-1-piperazinecarboxylate

→

title compound

المردود 156.2%

6-Fluoro-2-methyl-5-(1-piperazinyl)quinoline

المردود 156.2%

المذيبات

dioxane

dioxane

ظروف التفاعل

المعالجة

1. 1
   تركيزThe mixture was concentrated in vacuo
2. 2
   أخرىpartitioned between aqueous sodium hydroxide solution and DCM
3. 3
   غسيلThe combined organic phases were washed with brine
4. 4
   تجفيفdried over sodium sulfate
5. 5
   تركيزconcentrated

الإجراء التجريبي

A solution of hydrogen chloride in dioxane (4M, 4 mL) was added to a solution of 1,1-dimethylethyl-4-(6-fluoro-2-methyl-5-quinolinyl)-1-piperazinecarboxylate (0.178 g) in dioxane (4 mL) at 0° C. The resulting mixture was warmed to room temperature and stirred for 15 h. The mixture was concentrated in vacuo and partitioned between aqueous sodium hydroxide solution and DCM. The combined organic phases were washed with brine, dried over sodium sulfate and concentrated to afford the title compound (198 mg, 100% yield).

المصدر