تفاعل #4404

معادلة التفاعل

2-mercapto-1-[2-oxo-2-(2-pyridyl)ethyl]benzimidazole

Na2CO3

→

title compound

المردود 37.5%

2-(2-Pyridyl)thiazolo[3,2-a]benzimidazole

المردود 37.5%

المذيبات

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted into EtOAc (700 ml)
2. 2
   تجفيفThe extracts were dried (MgSO4)
3. 3
   أخرىevaporated
4. 4
   أخرىto give a solid which
5. 5
   أخرىwas recrystallised from EtOAc/EtOH

الإجراء التجريبي

A solution of 2-mercapto-1-[2-oxo-2-(2-pyridyl)ethyl]benzimidazole (1 g.) in polyphosphoric acid was heated at 140° C. for 1 hour. The solution was neutralised with Na2CO3 solution and extracted into EtOAc (700 ml). The extracts were dried (MgSO4) and evaporated to give a solid which was recrystallised from EtOAc/EtOH to give the title compound (0.35 g.) mp 222°-4° C.

المصدر