تفاعل #44038
ord-0d79eb667ed5444f8152a34c4d2c4fad
معادلة التفاعل
hydrazine hydrate
Benzyl 2-isopropyl-4-oxopiperidine-1-carboxylate
compound 67
benzyl 2-(4-chlorophenyl)-4-oxopiperidine-1-carboxylate
compound 50
piperidin-4-one
isopropylmagnesium chloride
→
benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
الإجراء التجريبي
Benzyl 2-isopropyl-4-oxopiperidine-1-carboxylate, prepared as described for compound 67 in Example 3 using isopropylmagnesium chloride, was formylated and treated with hydrazine hydrate as described for compound 50 in Example 1 to give benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate. This compound was then deprotected and treated with 4-chlorophenylsulfonyl chloride followed by NaOH as described for compound 52 in Example 1. The enantiomers were separated using HPLC Method [2].