تفاعل #43990

معادلة التفاعل

2-(2,3,4,5-tetramethylcyclopentadienyl)benzonitrile

2,4,6-trimethylphenyllithium

toluene

water

→

2-(2,3,4,5-tetramethylcyclopentadienyl)-α-(2,4,6-trimethylphenyl)-benzenemethanimine

المردود 108.1%

المذيبات

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىto separate an organic layer
2. 2
   أخرىThe organic layer was dried
3. 3
   workup.DISTILLATIONthe solvent was distilled off

الإجراء التجريبي

To a solution of 2-(2,3,4,5-tetramethylcyclopentadienyl)benzonitrile (6.3 mmol) in tetrahydrofuran (25.5 mL) was added dropwise a solution of 2,4,6-trimethylphenyllithium (12.5 mmol) in tetrahydrofuran (55.6 mL) at −78° C. under a nitrogen atmosphere. The temperature of the mixture was raised to room temperature and the mixture was stirred for 5 hrs. To the reaction mixture solution were added toluene and water to separate an organic layer and an aqueous layer. The organic layer was dried and the solvent was distilled off to give 2-(2,3,4,5-tetramethylcyclopentadienyl)-α-(2,4,6-trimethylphenyl)-benzenemethanimine (2.34 g) as a brown oily substance.

المصدر