تفاعل #43938

معادلة التفاعل

4-bromo-3,5-dimethylphenol

3-(methylthio)-1-propanol

tributylphosphine

1,1′-(azodicarbonyl)dipiperidine

→

title compound

المردود 87.0%

2-bromo-1,3-dimethyl-5-[3-(methylthio)propoxy]benzene

المردود 87.0%

المذيبات

Hexane

toluene

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe insoluble substance was filtered off
2. 2
   تركيزthe filtrate was concentrated under reduced pressure
3. 3
   أخرىThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=0:100-25:75)

الإجراء التجريبي

To a solution of 4-bromo-3,5-dimethylphenol (4.02 g, 20.0 mmol), 3-(methylthio)-1-propanol (2.12 g, 20.0 mmol) and tributylphosphine (7.97 mL, 32.0 mmol) in toluene (320 mL) was added 1,1′-(azodicarbonyl)dipiperidine (8.07 g, 32.0 mmol), and the mixture was stirred at room temperature for 18 hr under nitrogen atmosphere. Hexane (160 mL) was added to the reaction mixture, the insoluble substance was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=0:100-25:75) to give the title compound (5.03 g, yield 87%) as a pale-yellow oil.

المصدر