تفاعل #43923

معادلة التفاعل

ethyl 4-chloroacetoacetate

resorcinol

→

title compound

المردود 84.0%

4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

المردود 84.0%

المذيبات

sulfuric acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةUnder ice-cooling
2. 2
   ترشيحthe precipitated solid was collected by filtration
3. 3
   غسيلwashed with water
4. 4
   أخرىair-dried

الإجراء التجريبي

Under ice-cooling, ethyl 4-chloroacetoacetate (14.0 g, 85.0 mmol) was dissolved in concentrated sulfuric acid (30 mL), resorcinol (8.81 g, 80.0 mmol) was added by small portions, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water, and the precipitated solid was collected by filtration, washed with water, and air-dried to give the title compound (14.1 g, yield 84%) as a beige powder.

المصدر