تفاعل #43871

ord-b88e20db40de4ca08d1b693166dc5ab1

معادلة التفاعل

CCCc1nc2cc(N(Cc3ccccc3)C(=O)c3ccccc3F)ccc2n1CC(=O)OC(C)(C)C
{5-[Benzyl-(2-fluoro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester
O=C(O)C(F)(F)F
TFA
→
CCCc1nc2cc(N(Cc3ccccc3)C(=O)c3ccccc3F)ccc2n1CC(=O)O
title compound
CCCc1nc2cc(N(Cc3ccccc3)C(=O)c3ccccc3F)ccc2n1CC(=O)O
{5-[Benzyl-(2-fluoro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid

المتفاعلات

CCCc1nc2cc(N(Cc3ccccc3)C(=O)c3ccccc3F)ccc2n1CC(=O)OC(C)(C)C
{5-[Benzyl-(2-fluoro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester
O=C(O)C(F)(F)F
TFA

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    تركيزconcentrated
  2. 2
    أخرىpurified by preparative LCMS

الإجراء التجريبي

{5-[Benzyl-(2-fluoro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester (0.12 mmol) was treated with TFA (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. MS calculated for C26H24FN3O3+H: 446, observed: 446.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07732618B2uspto-grants-2010_06